The Blob (1988) ending / spoiler
Meg places a pack of explosive charges next to a couple of liquid nitrogen tanks, and when the charges go off, the blob is frozen. Some time later: the priest is preaching in another town about the end of the world. After the sermon, someone asks the priest "when will it happen?" and the priest reveals a jar with a piece of the blob and says "God will give me a sign..."
Submitted by Racer X